Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity

Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.

Epilepsy is a common neurological disease, manifested in unprovoked recurrent seizures. Epileptogenesis may develop due to genetic or pharmacological origins or following injury, but it remains unclear how the unaffected brain escapes this susceptibility to seizures. Here, we report that dynamic changes in forebrain microRNA (miR)-211 in the mouse brain shift the threshold for spontaneous and p...

Dynamic changes in murine forebrain miR - 211 expression associate with cholinergic imbalances and epileptiform activity

Cholinergic modulation of epileptiform activity in the developing rat neocortex.

The effects of carbachol on picrotoxin-induced epileptiform activity and membrane properties of neurons in the developing rat neocortex were examined in an in vitro slice preparation. Intracellular recordings were obtained in layer II-III neurons of slices prepared from rats 9-21 days of age. Epileptiform activity in 9- to 14-day-olds consisted of a sharply rising, sustained (10-30 s) membrane ...

Glutathione S Transferase Activity in the Basal Forebrain Cholinergic Population

The role of glutathione S transferase (GST) in the detoxification mechanisms in different organs is discussed in recent papers. In rat brain, where GST is located in the astrocytes/1-3/, the information concerning this topic is scarce. We present information about the levels of GST specific activity (GST-SA) in different rat brain areas and the effect of placental tissue homogenate (PTH), which...

Alcohol Abuse Promotes Changes in Non-Synaptic Epileptiform Activity with Concomitant Expression Changes in Cotransporters and Glial Cells

Non-synaptic mechanisms are being considered the common factor of brain damage in status epilepticus and alcohol intoxication. The present work reports the influence of the chronic use of ethanol on epileptic processes sustained by non-synaptic mechanisms. Adult male Wistar rats administered with ethanol (1, 2 e 3 g/kg/d) during 28 days were compared with Control. Non-synaptic epileptiform acti...